Research in the Gale laboratory is focused on understanding the processes that trigger and control innate immunity and inflammation to program the immune response against RNA virus infection, and to define the virus-host interactions that control viral replication and the outcome of infection and immunity. We are also focused on defining the systems biology and innate immune interactions of acute and chronic microbial infection toward building interventions to fight disease and improve global health.
The Gale laboratory has active research programs focused on understanding immune control of infection by:
- Flaviviruses including West Nile virus, Zika virus, Powassan virus, and others
- Hepatitis C and B viruses
- Oropouche virus
- Chikungunya virus
- HIV, SIV
- Hanta virus
- SARS-CoV-2 and contemporary coronaviruses
- Influenza viruses
The lab works closely with collaborators within academic, biotechnology, and pharmaceutical institutions in the USA and across the world to conduct research to build new or improved vaccines and therapeutics to enhance global health in the fight against virus infections.
Our research programs include:
- Innate Immune Adjuvant Discovery
- System Immunogenetics of Biodefense in the Collaborative Cross
- Innate Immune Antivirals for Biodefense
- The Host Response to Hepatitis C Virus
- The Host Response to West Nile Virus
- The Host Response to Zika Virus
We are committed to teaching and training scientists to be educators, researchers, and clinicians in the areas of immunology, virology, public and global health, systems biology, and microbial infection and immunity.